I've actually been using the latest version of JAWS recently, as part of my work on HTML5. From a usability point of view it is possibly the worst software I have ever used. I'm still horrified at how bad the accessibility situation is. All this time I've been hearing people worried about whether or not Web pages have longdesc attributes specified or whatnot, when in fact the biggest problems facing blind users are so much more fundamental as to make image-related issues seem almost trivial in comparison.