So long Safari?
My answer to So long Safari? on Ask MetaFilter
Safari has been out in the wild for less time, and also has a smaller number of people testing on it because it only runs on OS X. Here are a couple of issues that Safari suffers from that have affected me in the past:
2. preventDefault and stopPropagation don’t work in Safari (this may now have been fixed)
There’s a huge list of other bugs here.
In answer to the original question, I don’t see Safari going anywhere. It’s a great browser to develop for, and it’s getting less buggy all the time. The web development community’s shared understanding of its current bugs and their workarounds is growing constantly as well. I think it has a very bright future.