Optimizing for the mobile web: Moving from Angular to Preact. Grubhub reduced their mobile web load times from 9-11s to 3-4s by replacing Angular with Preact (and replacing other libraries such as lodash with native JavaScript code). The conversion took 6 months and involved running Angular and Preact simultaneously during the transition—not a huge additional overhead as Preact itself is only 4KB. They used TypeScript throughout and credit it with providing a great deal of confidence and productivity to the overall refactoring.
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